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Isotodesnitazene for sale (also known as desnitroetonitazene, etazen, etazene, and etazone) is a benzimidazole-derived opioid analgesic drug, which was originally developed in the late 1950s alongside etonitazene and a range of related derivatives.It is many times less potent than etonitazene itself, but still 70 times more potent than morphine in animal studies. Corresponding analogues where the N,N-diethyl group is replaced by piperidine or pyrrolidine rings also retain significant activity (10 times and 20 times morphine, respectively).Etodesnitazene has been sold as a designer drug, first being identified in both Poland and Finland in March 2020.

Etodesnitazene is classified as a novel opioid of the benzimidazole sub-class and is
structurally dissimilar from fentanyl. Novel opioids have been reported to cause psychoactive
effects similar to heroin, fentanyl, and other opioids. Novel opioids have also caused adverse
events, including death, as described in the literature. Structurally similar compounds include
etonitazene, metonitazene, and isotonitazene; however, these substances contain a nitro moiety
attached to the benzimidazole core. Etonitazene and its analogue synthetic opioids were first
synthesized and reported in the literature in the 1950s.1 Data suggest that this group of nitrocontaining analogues can have potency similar to or greater than fentanyl.2 Recent in vitro data
suggest that etodesnitazene is less potent than fentanyl.3 Etodesnitazene is not explicitly
scheduled in the United States; however, etonitazene and isotonitazene are Schedule I
substances